HIV epidemic has caused a health crisis globally. We have analyzed and modeled data from animal models of HIV, HSV and influenza virus, aiming to understand the role of neutralizing antibodies (nAbs), CD4+ T cells, CTLs and APCs in HIV infection. Our analysis demonstrates that passive antibodies confer protection against macaque SHIV89.6P by either neutralizing the initial viral inoculums or reducing the acute viral growth. Therefore, vaccines that elicit high nAb levels during early infection may induce sterilizing immunity or delay disease progression. We further show a positive correlation between peak viral level and the acute CD4+ T cell depletion in SHIV89.6P infection, which implies that reduction of peak viral level significantly preserves CD4+ T cells. Further study on influenza and HSV-1 infections suggests that antigen loading rate of APC determines the magnitude of antigen presentation and the APC decay is mainly due to the degradation of pMHC, not CTL killing. The slow kinetics of HIV viral growth may be one factor that limits the level of antigen presentation and subsequent CTL response. This book should be helpful for virologists, epidemiologists and HIV researchers.
Produktkennzeichnungen
ISBN-10
3836462850
ISBN-13
9783836462853
eBay Product ID (ePID)
70228550
Produkt Hauptmerkmale
Sprache
Englisch
Anzahl der Seiten
184 Seiten
Verlag
Vdm Verlag
Publikationsname
Viral-Immune Interaction in Hiv Infection
Autor
Lei Zhang
Format
Taschenbuch
Erscheinungsjahr
2008
Zusätzliche Produkteigenschaften
Hörbuch
No
Inhaltsbeschreibung
Paperback
Item Length
22cm
Item Height
1cm
Item Width
15cm
Item Weight
290g
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