For thousands of years nature has played an important role in providing mankind with life-saving drugs. Several natural products have been clinically approved and they continue to remain as valuable medicines. However, in cases where the supply of an active natural product is limited, total synthesis is often the only means by which sufficient quantities could be generated for therapeutic use. Additionally, such a process could unveil novel pharmacophores which could serve as templates for designing new drugs. Himbacine, himgaline, and GB13 belong to a family of alkaloids isolated from the bark of a rain forest tree, Galbulimima belgraveana. While himbacine has been extensively studied for its antimuscarinic activity, the biological properties of its more complex congeners remain unexplored. This book describes total syntheses of both the enantiomers of himgaline and GB13. Key manipulations involved a Diels-Alder reaction, an aldol-type cascade cyclization, an aza-Michael reaction, and a hydroxyl-directed stereoselective ketone reduction. This synthetic achievement paves the way for future exploration of the medicinal value of compounds described herein and other related natural products.
Produktkennzeichnungen
EAN
9783639004823
ISBN
9783639004823
ISBN-10
3639004825
ISBN-13
9783639004823
eBay Product ID (ePID)
69871982
Produkt Hauptmerkmale
Sprache
Englisch
Anzahl der Seiten
244 Seiten
Verlag
Vdm Verlag, Vdm
Publikationsname
Total Synthesis of Galbulimima Alkaloids: Himgaline And Gb13
Autor
U. Shah, S. Chackalamannil, A. K. Ganguly
Format
Taschenbuch
Erscheinungsjahr
2008
Maße
Gewicht
330g
Zusätzliche Produkteigenschaften
Hörbuch
No
Inhaltsbeschreibung
Paperback
Item Length
22cm
Item Height
1cm
Item Width
15cm
Mitautor
S. Chackalamannil, A. K. Ganguly
Sprachausgabe
Englisch
Seiten
244 Seiten
Item Weight
380g
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